从精准医学的视角看中医药防治慢性胃炎“炎癌转化”

丁霞; 李园; 沈洪

doi:10.3969/j.issn.1006-2157.2023.03.005

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从精准医学的视角看中医药防治慢性胃炎“炎癌转化”

理论研究 | 更新时间：2023-04-07

- 从精准医学的视角看中医药防治慢性胃炎“炎癌转化”
- Prevention and treatment of "inflammation cancer transformation" of chronic gastritis with traditional Chinese medicine from the perspective of precision medicine
- 北京中医药大学学报 2023年46卷第3期页码：315-320
- 作者机构：
  
  1.北京中医药大学中医学院　北京　100029
  2.北京中医药大学国家中医体质与治未病研究院
  3.南京中医药大学附属医院
- 作者简介：
  
  Prof. DING Xia, Ph.D., Chief Physician, Doctoral Supervisor. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine. No.11, Beisanhuan Donglu, Chaoyang District. Beijing 100029. E-mail: dingx@bucm.edu.cn
- 基金信息：
  
  国家自然科学基金重大研究计划项目(92059102);国家自然科学基金重点项目(81630080);国家自然科学基金青年科学基金项目(82205095)
- DOI：10.3969/j.issn.1006-2157.2023.03.005
  中图分类号： R256.3
- 纸质出版日期：2023-03-30，
  
  网络出版日期：2022-12-16，
  
  收稿日期：2022-11-04，
- 稿件说明：
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丁霞, 李园, 沈洪. 从精准医学的视角看中医药防治慢性胃炎“炎癌转化”[J]. 北京中医药大学学报, 2023,46(3):315-320.

DING Xia, LI Yuan, SHEN Hong. Prevention and treatment of "inflammation cancer transformation" of chronic gastritis with traditional Chinese medicine from the perspective of precision medicine[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(3):315-320.
丁霞, 李园, 沈洪. 从精准医学的视角看中医药防治慢性胃炎“炎癌转化”[J]. 北京中医药大学学报, 2023,46(3):315-320. DOI： 10.3969/j.issn.1006-2157.2023.03.005.

DING Xia, LI Yuan, SHEN Hong. Prevention and treatment of "inflammation cancer transformation" of chronic gastritis with traditional Chinese medicine from the perspective of precision medicine[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023,46(3):315-320. DOI： 10.3969/j.issn.1006-2157.2023.03.005.

摘要

精准医学是依据患者内在生物学信息、临床症状和体征，对患者实施“量身定制”的健康医疗和临床决策，在胃癌的生物学标志物分析、鉴定和靶向治疗，以及外科手术的微创化和精准化发展方面取得了重大突破。中医学是以高度“个体化医疗”为特点的医学，关注体质、环境、生活方式等多种因素对个体的影响。慢性胃炎“炎癌转化”是横跨消化和肿瘤两个学科，涉及多病理阶段、动态演变的复杂过程。中医学以“治未病”思想为指导，尤其注重对慢性胃炎“炎癌转化”形成全过程、全因素、全图景的精准防治策略，旨在针对不同病理阶段、不同证候特点、不同人群特征进行分阶段的精准管理，在慢性胃炎“炎癌转化”的每一个病理阶段形成主动干预的“理、法、方、药”，从而截断其向下一阶段的进展路径，实现降低胃癌发病率的目标。从精准医学视角，探讨中医药对于慢性胃炎“炎癌转化”精准认识、精准预防、精准辨证、精准施治的全过程管理优势，以期为延缓、阻断乃至逆转慢性胃炎“炎癌转化”进程提供参考和借鉴。

Abstract

Precision medicine refers to implement "tailored" health care and clinical decision-making based on the patient’s intrinsic biological information and clinical signs. Major breakthroughs have been made not only in targeted therapy of gastric cancer and in the analysis and identification of biological markers

but also in the development of minimally invasive and precise surgery. Traditional Chinese medicine is a system that is characterized by a high degree of "individualized medicine"

where attention is paid to the influence of various factors such as constitution

environment

and lifestyle on individual differences. "Inflammation cancer transformation" of chronic gastritis is a complex process that encompasses the digestology and oncology

involving a dynamic evolution that spans multiple pathological stages. Guided by the ideology of "preventive treatment"

Chinese medicine pays special attention to the precise prevention and treatment across the whole process and all factors involved in "inflammation cancer transformation" of chronic gastritis. The ultimate aim is to provide (i) targeted and precise management for different pathological stages

different syndrome characteristics

and different population characteristics; and (ii) active intervention based on "principle

methodology

formula

medication" at each pathological stage

so as to block disease progression and reduce the incidence of gastric cancer. This paper discusses the advantages of traditional Chinese medicine in precision medicine

from the perspective of accuracy in theory

prevention

differentiation

and treatment

in order to provide a reference for delaying

blocking

or even reversing the process of "inflammatory cancer transformation" of chronic gastritis.

关键词

精准医学慢性胃炎胃癌炎癌转化中医药

Keywords

precision medicinechronic gastritisgastric cancerinflammation cancer transformationtraditional Chinese medicine

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