双心方对经皮冠脉介入术术后合并抑郁状态心血瘀阻证患者的血清成分影响及相关性分析

刘祥; 侯季秋; 赵海滨; 王超

doi:10.3969/j.issn.1006-2157.2023.07.005

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双心方对经皮冠脉介入术术后合并抑郁状态心血瘀阻证患者的血清成分影响及相关性分析

“中医药防治心血管疾病”专题 | 更新时间：2023-08-07

- 双心方对经皮冠脉介入术术后合并抑郁状态心血瘀阻证患者的血清成分影响及相关性分析
- Effect and correlation analysis of Shuangxin Formula on serum components of depression after percutaneous coronary intervention in patients with syndrome of heart blood stasis
- 北京中医药大学学报 2023年46卷第7期页码：913-923
- 作者机构：
  
  1.北京中医药大学　北京　100029
  2.北京中医药大学东方医院
- 作者简介：
  
  刘祥，女，在读博士生
  # 赵海滨，男，博士，主任医师，教授，博士生导师，主要研究方向：中医药防治心血管疾病，E-mail：haibin999@126.com
- 基金信息：
  
  国家自然科学基金项目(82174332);北京市自然科学基金(7202126);北京市中医药科技发展资金项目(JJ-2020-38)
- DOI：10.3969/j.issn.1006-2157.2023.07.005
  中图分类号： R259
- 收稿日期：2023-03-03，
  
  网络出版日期：2023-05-11，
  
  纸质出版日期：2023-07-30
- 稿件说明：
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刘祥, 侯季秋, 赵海滨, 等. 双心方对经皮冠脉介入术术后合并抑郁状态心血瘀阻证患者的血清成分影响及相关性分析[J]. 北京中医药大学学报, 2023,46(7):913-923.

LIU Xiang, HOU Jiqiu, ZHAO Haibin, et al. Effect and correlation analysis of Shuangxin Formula on serum components of depression after percutaneous coronary intervention in patients with syndrome of heart blood stasis[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(7): 913-923.
刘祥, 侯季秋, 赵海滨, 等. 双心方对经皮冠脉介入术术后合并抑郁状态心血瘀阻证患者的血清成分影响及相关性分析[J]. 北京中医药大学学报, 2023,46(7):913-923. DOI： 10.3969/j.issn.1006-2157.2023.07.005.

LIU Xiang, HOU Jiqiu, ZHAO Haibin, et al. Effect and correlation analysis of Shuangxin Formula on serum components of depression after percutaneous coronary intervention in patients with syndrome of heart blood stasis[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(7): 913-923. DOI： 10.3969/j.issn.1006-2157.2023.07.005.

摘要

目的

观察双心方对经皮冠脉介入术(PCI)术后合并抑郁状态心血瘀阻证患者血清中超敏C反应蛋白(hs-CRP)、白细胞介素－6(IL-6)、5－羟色胺(5-HT)、促肾上腺皮质激素(ACTH)及皮质醇(COR)的影响。

方法

选取2021年4—12月就诊于北京中医药大学东方医院病房及门诊符合纳入标准的72例患者，根据随机数字表法分为试验组和对照组，每组36例。对照组予PCI术后的常规西药＋安慰剂，试验组予常规西药＋双心方，治疗期为4周。采用酶联免疫吸附测定检测试验组和对照组治疗前后的外周血清中hs-CRP、IL-6、5-HT、ACTH及COR的含量，并进行相关性分析。比较患者治疗前后的中医证候量化总分、中医症状单项评分。

结果

治疗4周后，2组患者血清中的hs-CRP、IL-6、ACTH及COR含量较治疗前下降(

0.01)，且试验组患者的hs-CRP、IL-6、ACTH及COR含量低于对照组(

0.01)。治疗4周后，2组患者血清中的5-HT含量较治疗前升高(

0.01)，且试验组患者的5-HT含量高于对照组(

0.01)。治疗前后，2组患者血清中的5-HT含量与hs-CRP、IL-6含量均呈负相关(

0.05，

0.01)，hs-CRP、IL-6含量与ACTH、COR含量均呈正相关(

0.05，

0.01)，5-HT与ACTH、COR含量均呈负相关(

0.01)。治疗后，2组患者中医证候量化总分和中医症状单项评分均较治疗前降低(

0.05，

0.01)，试验组患者中医证候量化总分和中医症状单项评分低于对照组(

0.01)。

结论

双心方可能通过下调炎症因子hs-CRP、IL-6而降低炎症反应，进而增加5-HT的含量，降低下丘脑－垂体－肾上腺轴相关因子ACTH及COR含量，发挥双心同治的作用。

Abstract

Objective

To observe the effects of

Shuangxin

Formula on hypersensitive C-reactive protein (hs-CRP)

interleukin-6 (IL-6)

5-hydroxytryptamine (5-HT)

adrenocorticotrophic hormone (ACTH) and cortisol (COR) in patients with depression after percutaneous coronary intervention (PCI) with syndrome of heart blood stasis.

Methods

Patients admitted to wards and outpatients of Dongfang Hospital

Beijing University of Chinese Medicine between April 2021 and December 2021 were selected. According to a random number table

72 patients who met the inclusion criteria were divided into the experimental group and the control group

with 36 cases per group. The control group was treated with conventional western medicine after PCI

and placebo. The experimental group was treated with conventional western medicine after PCI and

Shuangxin

Formula. The treatment period for both groups was 4 weeks. The serum levels of hs-CRP

IL-6

5-HT

ACTH

and COR in the experimental group and the control group before and after treatment were determined by enzyme-linked immunosorbent assay

and the correlation was analyzed. The total quantitative score of traditional Chinese medicine syndrome and the single score of traditional Chinese medicine symptoms were compared before and after treatment.

Results

After 4 weeks’ treatment

the serum levels of hs-CRP

IL-6

ACTH

and COR in the two groups decreased(

0.01)

and the levels of hs-CRP

IL-6

ACTH

and COR in the experimental group were lower than in the control group (

0.01). After 4 weeks’ treatment

the serum level of 5-HT was higher than before treatment in both group (

0.01)

and the serum level of 5-HT in the experimental group was higher than in the control group (

0.01). Before and after treatment

the level of 5-HT was negatively correlated with the serum levels of hs-CRP and IL-6 in the two groups (

0.05

0.01); the levels of hs-CRP and IL-6 were positively correlated with the levels of ACTH and COR (

0.05

0.01); and the level of 5-HT was negatively correlated with the levels of ACTH and COR (

0.01). After treatment

the total quantitative score of traditional Chinese medicine syndrome and the single score of traditional Chinese medicine symptoms in both groups were lower than those before treatment (

0.05

0.01). The total quantitative score of traditional Chinese medicine syndrome and the single score of traditional Chinese medicine symptoms in the experimental group were lower than in the control group (

0.01).

Conclusion

Shuangxin

Formula may reduce the inflammatory response by reducing the levels of the inflammatory factors hs-CRP and IL-6

and then upregulating the excitability of 5-HT

and inhibiting the levels of the HPA axis-related factors ACTH and COR

thus playing the role of spirit-heart treatment.

关键词

Keywords

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