基于“少火生气，壮火食气”理论探析2型糖尿病进程中胰岛巨噬细胞对β细胞功能变化的影响

张钰莹; 黄薇宇; 袁颢瑜; 王保华; 李赛美

doi:10.3969/j.issn.1006-2157.2025.01.003

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基于“少火生气，壮火食气”理论探析2型糖尿病进程中胰岛巨噬细胞对β细胞功能变化的影响

“中医药防治糖尿病及其并发症”专题 | 更新时间：2025-01-27

- 基于“少火生气，壮火食气”理论探析2型糖尿病进程中胰岛巨噬细胞对β细胞功能变化的影响
- Effect of islet macrophages on β-cell function changes during type 2 diabetes mellitus progression based on the "moderate fire generating qi, hyperactive fire consuming qi" theory
- 北京中医药大学学报 2025年48卷第1期页码：14-20
- 作者机构：
  
  1.广州中医药大学第一临床医学院　广州　510006
  2.广州中医药大学第一附属医院
- 作者简介：
  
  张钰莹，女，在读博士生
  #李赛美，女，博士，教授，主任医师，博士生导师，主要研究方向：中医药防治内分泌疾病，E-mail：lisaimei2004@163.com
- 基金信息：
  
  National Natural Science Foundation of China(82104791)
- DOI：10.3969/j.issn.1006-2157.2025.01.003
  中图分类号： R259.871
- 纸质出版日期：2025-01-30，
  
  网络出版日期：2024-12-10，
  
  收稿日期：2024-07-16，
- 稿件说明：
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张钰莹, 黄薇宇, 袁颢瑜, 等. 基于“少火生气，壮火食气”理论探析2型糖尿病进程中胰岛巨噬细胞对β细胞功能变化的影响[J]. 北京中医药大学学报, 2025,48(1):14-20.

ZHANG YUYING, HUANG WEIYU, YUAN HAOYU, et al. Effect of islet macrophages on β-cell function changes during type 2 diabetes mellitus progression based on the "moderate fire generating qi, hyperactive fire consuming qi" theory. [J]. Journal of beijing university of traditional chinese medicine, 2025, 48(1): 14-20.
张钰莹, 黄薇宇, 袁颢瑜, 等. 基于“少火生气，壮火食气”理论探析2型糖尿病进程中胰岛巨噬细胞对β细胞功能变化的影响[J]. 北京中医药大学学报, 2025,48(1):14-20. DOI： 10.3969/j.issn.1006-2157.2025.01.003.

ZHANG YUYING, HUANG WEIYU, YUAN HAOYU, et al. Effect of islet macrophages on β-cell function changes during type 2 diabetes mellitus progression based on the "moderate fire generating qi, hyperactive fire consuming qi" theory. [J]. Journal of beijing university of traditional chinese medicine, 2025, 48(1): 14-20. DOI： 10.3969/j.issn.1006-2157.2025.01.003.

摘要

本文基于“少火生气，壮火食气”理论探讨2型糖尿病(T2DM)进程中胰岛巨噬细胞对β细胞功能变化的影响。T2DM与慢性低度炎症密切相关，胰岛巨噬细胞在这一过程中发挥关键作用。生理状态下，胰岛巨噬细胞通过分泌抗炎因子和生长因子，适度调节免疫反应，促进细胞增殖，维持胰岛β细胞的存活和功能，发挥类似于“少火生气”的作用。在T2DM的病理过程中，胰岛巨噬细胞过度活化，功能失调，分泌大量促炎因子，引发严重的炎症反应和氧化应激，直接损伤胰岛β细胞，并破坏胰岛微环境和血供，加剧局部炎症和结构损伤，恶化β细胞的生存环境，最终导致胰岛β细胞的数量减少和功能丧失，与“壮火食气”理论中亢盛之火导致机体气血耗伤的过程相吻合。本文探讨中医学理论在西医学中的理解与应用，并为T2DM的防治提供了新的视角，调控胰岛巨噬细胞功能、减弱其促炎反应，可能成为保护β细胞功能、延缓T2DM进程的关键策略。

Abstract

This study examined the effect of islet macrophages on β-cell function changes during type 2 diabetes mellitus (T2DM) progression based on the traditional Chinese medicine theory that " moderate fire generating qi

hyperactive fire consuming qi" . T2DM is closely associated with chronic low-grade inflammation

with islet macrophages playing a central role in this process. Under physiological conditions

islet macrophages secrete anti-inflammatory and growth factors to regulate the immune response

promote cell proliferation

and support islet β-cell survival and function

reflecting the concept of " moderate fire generating qi" . However

during the pathological process of T2DM

islet macrophages become over-activated and dysfunctional

secreting large amounts of pro-inflammatory factors that trigger severe inflammatory responses and oxidative stress. This process damages islet β-cells

disrupts the islet microenvironment and blood supply

exacerbates local inflammation and structural damage

and worsens the survival environment of β-cells. Ultimately

this leads to fewer β-cells and function loss

aligning with the " hyperactive fire consuming qi" theory

where excessive fire depletes qi and blood. This study enhances the understanding and application of traditional Chinese medicine theories in modern medicine

offering a new perspective on T2DM prevention and treatment. Regulating islet macrophage function and reducing their pro-inflammatory responses may become key strategies for preserving β-cell function and slowing T2DM progression.

关键词

2型糖尿病胰岛巨噬细胞胰岛β细胞少火生气壮火食气

Keywords

type 2 diabetes mellitusislet macrophagesislet β-cellsmoderate fire generating qihyperactive fire consuming qi

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